Detecting intermediate protein conformations using algebraic topology

Detecting intermediate protein conformations using algebraic topology

Abstract Background Understanding protein structure and dynamics is essential for understanding their function. This is a challenging task due to the high complexity of the conformational landscapes of proteins and their rugged energy levels. In particular, it is important to detect highly populated...

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Bibliographic Details
Main Authors: Nurit Haspel, Dong Luo, Eduardo González
Format: Article
Language:English
Published: BMC 2017-12-01
Series:BMC Bioinformatics
Subjects:
Algebraic topology
Protein conformational sampling
Clustering
Protein structure
Dimensionality reduction
Online Access:http://link.springer.com/article/10.1186/s12859-017-1918-z

Internet

http://link.springer.com/article/10.1186/s12859-017-1918-z

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