Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors

Distinct mutational processes shape selection of MHC class I and class II mutations across primary and metastatic tumors

Summary: Disruption of antigen presentation via loss of major histocompatibility complex (MHC) expression is a strategy whereby cancer cells escape immune surveillance and develop resistance to immunotherapy. Here, we develop the personalized genomics algorithm Hapster and accurately call somatic mu...

Full description

Bibliographic Details
Main Authors: Michael B. Mumphrey, Noshad Hosseini, Abhijit Parolia, Jie Geng, Weiping Zou, Malini Raghavan, Arul Chinnaiyan, Marcin Cieslik
Format: Article
Language:English
Published: Elsevier 2023-08-01
Series:Cell Reports
Subjects:
CP: Cancer
CP: Immunology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723009762

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723009762

Similar Items