Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas

Mutation and genomic amplification of the PIK3CA proto-oncogene in pituitary adenomas

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The tumorigenesis of pituitary adenomas is poorly understood. Mutations of the PIK3CA proto-oncogene, which encodes the p110-α catalytic subunit of PI3K, have been reported in various types of human cancers regarding the role of the gene in cell proliferation and survival through activation...

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Bibliographic Details
Main Authors: C.B. Murat, P.B.S. Braga, M.A.H.Z. Fortes, M.D. Bronstein, M.L.C. Corrêa-Giannella, R.R. Giorgi
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2012-09-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
Pituitary adenomas
PIK3CA proto-oncogene
Genomic amplification
Somatic mutation
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900009

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000900009

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