Characterization of changes in the tyrosine pathway by 24-h profiling during nitisinone treatment in alkaptonuria

Characterization of changes in the tyrosine pathway by 24-h profiling during nitisinone treatment in alkaptonuria

Background: Although changes in the tyrosine pathway during nitisinone therapy are known, a complete characterization of the induced tyrosinaemia is lacking to improve disease management. Patients and methods: Our research aims were addressed by 24-h blood sampling. 40 patients with alkaptonuria (AK...

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Bibliographic Details
Main Authors: L.R. Ranganath, A.M. Milan, A.T. Hughes, A.S. Davison, M. Khedr, B.P. Norman, G. Bou-Gharios, J.A. Gallagher, M. Gornall, R. Jackson, R. Imrich, J. Rovensky, M. Rudebeck, B. Olsson
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Molecular Genetics and Metabolism Reports
Subjects:
Alkaptonuria
Homogentisic acid
Tyrosine
Hydroxyphenylpyruvate
Hydroxyphenyllactate
Phenylalanine
Online Access:http://www.sciencedirect.com/science/article/pii/S2214426922000064

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http://www.sciencedirect.com/science/article/pii/S2214426922000064

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