XIAP Regulates Caspase Activity in Degenerating Axons

Our knowledge of the destructive events that regulate axonal degeneration is rudimentary. Here, we examine the role of caspases and their endogenous inhibitor, the X-linked inhibitor of apoptosis protein (XIAP), in axonal degeneration of dorsal root ganglion (DRG) axons. We show that caspase-3, casp...

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Bibliographic Details
Main Authors: Nicolas Unsain, Julia M. Higgins, Kristen N. Parker, Aaron D. Johnstone, Philip A. Barker
Format: Article
Language:English
Published: Elsevier 2013-08-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713003628