Survival advantage of native and engineered T cells is acquired by mitochondrial transfer from mesenchymal stem cells

Survival advantage of native and engineered T cells is acquired by mitochondrial transfer from mesenchymal stem cells

Abstract Background Apoptosis, a form of programmed cell death, is critical for the development and homeostasis of the immune system. Chimeric antigen receptor T (CAR-T) cell therapy, approved for hematologic cancers, retains several limitations and challenges associated with ex vivo manipulation, i...

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Bibliographic Details
Main Authors: Angela C. Court, Eliseo Parra-Crisóstomo, Pablo Castro-Córdova, Luiza Abdo, Emmanuel Arthur Albuquerque Aragão, Rocío Lorca, Fernando E. Figueroa, Martín Hernán Bonamino, Maroun Khoury
Format: Article
Language:English
Published: BMC 2024-09-01
Series:Journal of Translational Medicine
Subjects:
Mesenchymal stromal/stem cells
Chimeric antigen receptor T (CAR-T) cells
Mitochondria transfer
Induced-apoptosis
Online Access:https://doi.org/10.1186/s12967-024-05627-4

Internet

https://doi.org/10.1186/s12967-024-05627-4

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