Irreversible Antagonists for the Adenosine A<sub>2B</sub> Receptor

Irreversible Antagonists for the Adenosine A<sub>2B</sub> Receptor

Blockade of the adenosine A<sub>2B</sub> receptor (A<sub>2B</sub>AR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A<sub>2B</sub>AR antagonists based on an 8-&l...

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Bibliographic Details
Main Authors: Ahmed Temirak, Jonathan G. Schlegel, Jan H. Voss, Victoria J. Vaaßen, Christin Vielmuth, Tobias Claff, Christa E. Müller
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
adenosine
BRET assay
covalent binding
Gα<sub>15</sub>
G protein activation
G protein-coupled receptor
Online Access:https://www.mdpi.com/1420-3049/27/12/3792

Internet

https://www.mdpi.com/1420-3049/27/12/3792

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