Irreversible Antagonists for the Adenosine A<sub>2B</sub> Receptor

Irreversible Antagonists for the Adenosine A<sub>2B</sub> Receptor

Blockade of the adenosine A<sub>2B</sub> receptor (A<sub>2B</sub>AR) represents a potential novel strategy for the immunotherapy of cancer. In the present study, we designed, synthesized, and characterized irreversible A<sub>2B</sub>AR antagonists based on an 8-&l...

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Bibliographic Details
Main Authors:	Ahmed Temirak, Jonathan G. Schlegel, Jan H. Voss, Victoria J. Vaaßen, Christin Vielmuth, Tobias Claff, Christa E. Müller
Format:	Article
Language:	English
Published:	MDPI AG 2022-06-01
Series:	Molecules
Subjects:	adenosine BRET assay covalent binding Gα<sub>15</sub> G protein activation G protein-coupled receptor
Online Access:	https://www.mdpi.com/1420-3049/27/12/3792

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