L‐BAIBA Synergizes with Sub‐Optimal Mechanical Loading to Promote New Bone Formation

ABSTRACT The L‐enantiomer of β‐aminoisobutyric acid (BAIBA) is secreted by contracted muscle in mice, and exercise increases serum levels in humans. In mice, L‐BAIBA reduces bone loss with unloading, but whether it can have a positive effect with loading is unknown. Since synergism can be more easil...

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Bibliographic Details
Main Authors: Matt Prideaux, Alberto Smargiassi, Gang Peng, Marco Brotto, Alexander G Robling, Lynda F Bonewald
Format: Article
Language:English
Published: Wiley 2023-06-01
Series:JBMR Plus
Subjects:
Online Access:https://doi.org/10.1002/jbm4.10746