SIGIRR deficiency contributes to CD4 T cell abnormalities by facilitating the IL1/C/EBPβ/TNF-α signaling axis in rheumatoid arthritis

SIGIRR deficiency contributes to CD4 T cell abnormalities by facilitating the IL1/C/EBPβ/TNF-α signaling axis in rheumatoid arthritis

Abstract Background Rheumatoid arthritis (RA) is a complex autoimmune disease with multiple etiological factors, among which aberrant memory CD4 T cells activation plays a key role in the initiation and perpetuation of the disease. SIGIRR (single immunoglobulin IL-1R-related receptor), a member of t...

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Bibliographic Details
Main Authors: Xiu Teng, Da-Chao Mou, Hui-Fang Li, Ling Jiao, Sha-Sha Wu, Jin-Kui Pi, Yan Wang, Meng-Li Zhu, Meng Tang, Yi Liu
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Molecular Medicine
Subjects:
Single immunoglobulin interleukin-1 receptor (SIGIRR)
Rheumatoid arthritis (RA)
CD4 T cells
Tumor necrosis factor (TNF)
CCAAT/enhancer-binding protein β (C/EBP β)
Online Access:https://doi.org/10.1186/s10020-022-00563-9

Internet

https://doi.org/10.1186/s10020-022-00563-9

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