Permeability of the Perindopril Arginine under In Vitro Conditions across Caco-2 Monolayer and Biomimetic Phospholipid Membrane

Permeability of the Perindopril Arginine under In Vitro Conditions across Caco-2 Monolayer and Biomimetic Phospholipid Membrane

Perindopril arginine (PA) as an angiotensin-converting enzyme (ACE) inhibitor is widely used in cardiovascular diseases, especially in systemic hypertension and heart failure. Although the pharmacokinetics of PA are well documented, there is no available detailed data on its permeation in in vitro c...

Full description

Bibliographic Details
Main Authors: Marta Kus, Klaudia Gorniak, Piotr Czaklosz, Anna Olejnik, Paulina Skupin-Mrugalska, Izabela Ibragimow, Hanna Piotrowska-Kempisty
Format: Article
Language:English
Published: MDPI AG 2022-03-01
Series:Molecules
Subjects:
perindopril arginine
permeability
Caco-2 monolayer
PermeaPad<sup>®</sup> 96-well plate
simple diffusion
intestinal absorption
Online Access:https://www.mdpi.com/1420-3049/27/7/2232

Internet

https://www.mdpi.com/1420-3049/27/7/2232

Similar Items