Targeting Wnt/β-catenin signaling using XAV939 nanoparticles in tumor microenvironment-conditioned macrophages promote immunogenicity

Targeting Wnt/β-catenin signaling using XAV939 nanoparticles in tumor microenvironment-conditioned macrophages promote immunogenicity

The aberrant activation of Wnt/β-catenin signaling in tumor cells and immune cells in the tumor microenvironment (TME) promotes malignant transformation, metastasis, immune evasion, and resistance to cancer treatments. The increased Wnt ligand expression in TME activates β-catenin signaling in antig...

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Bibliographic Details
Main Authors: Chetan Pundkar, Ferrin Antony, Xuejia Kang, Amarjit Mishra, R. Jayachandra Babu, Pengyu Chen, Feng Li, Amol Suryawanshi
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Heliyon
Subjects:
Tumor microenvironment
β-catenin
XAV939
Nanoparticle
Wnt
Tumor-associated macrophages
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844023038951

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http://www.sciencedirect.com/science/article/pii/S2405844023038951

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