WWC Proteins: Important Regulators of Hippo Signaling in Cancer

The Hippo signaling pathway is known to regulate cell differentiation, proliferation and apoptosis. Whereas activation of the Hippo signaling pathway leads to phosphorylation and cytoplasmic retention of the transcriptional coactivator YAP, decreased Hippo signaling results in nuclear import of YAP...

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Bibliographic Details
Main Authors: Verena Höffken, Anke Hermann, Hermann Pavenstädt, Joachim Kremerskothen
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
Online Access:https://www.mdpi.com/2072-6694/13/2/306