Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages

Neural precursor cell delivery induces acute post-ischemic cerebroprotection, but fails to promote long-term stroke recovery in hyperlipidemic mice due to mechanisms that include pro-inflammatory responses associated with brain hemorrhages

Abstract Background The intravenous delivery of adult neural precursor cells (NPC) has shown promising results in enabling cerebroprotection, brain tissue remodeling, and neurological recovery in young, healthy stroke mice. However, the translation of cell-based therapies to clinical settings has en...

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Bibliographic Details
Main Authors: Dongpei Yin, Chen Wang, Yachao Qi, Ya-Chao Wang, Nina Hagemann, Ayan Mohamud Yusuf, Egor Dzyubenko, Britta Kaltwasser, Tobias Tertel, Bernd Giebel, Matthias Gunzer, Aurel Popa-Wagner, Thorsten R. Doeppner, Dirk M. Hermann
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Neuroinflammation
Subjects:
Anti-inflammation
Cholesterol-rich diet
Focal cerebral ischemia
Hypercholesterolemia
Light sheet microscopy
Microglia/macrophage morphology
Online Access:https://doi.org/10.1186/s12974-023-02894-8

Internet

https://doi.org/10.1186/s12974-023-02894-8

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