Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability

Lactulose and Melibiose Inhibit α-Synuclein Aggregation and Up-Regulate Autophagy to Reduce Neuronal Vulnerability

Parkinson’s disease (PD) is a neurodegenerative disease characterized by selective dopaminergic (DAergic) neuronal degeneration in the substantia nigra (SN) and proteinaceous α-synuclein-positive Lewy bodies and Lewy neuritis. As a chemical chaperone to promote protein stability and an autophagy ind...

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Bibliographic Details
Main Authors: Chiung Mei Chen, Chih-Hsin Lin, Yih-Ru Wu, Chien-Yu Yen, Yu-Ting Huang, Jia-Lan Lin, Chung-Yin Lin, Wan-Ling Chen, Chih-Ying Chao, Guey-Jen Lee-Chen, Ming-Tsan Su, Kuo-Hsuan Chang
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Cells
Subjects:
Parkinson’s disease
lactulose
melibiose
α-synuclein aggregation inhibition
autophagy inducer
Online Access:https://www.mdpi.com/2073-4409/9/5/1230

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https://www.mdpi.com/2073-4409/9/5/1230

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