FBXO22 promotes glioblastoma malignant progression by mediating VHL ubiquitination and degradation

FBXO22 promotes glioblastoma malignant progression by mediating VHL ubiquitination and degradation

Abstract Glioblastoma (GBM) is the most common malignant primary brain tumor. Despite comprehensive treatment with traditional surgery, radiotherapy, and chemotherapy, the median survival rate is <14.6% and the 5-year survival rate is only 5%. FBXO22, a substrate receptor of the SCF ubiquitin lig...

Full description

Bibliographic Details
Main Authors: Zhigang Shen, Tao Dong, Hongmei Yong, Chuyin Deng, Changxiu Chen, Xintian Chen, Miaolei Chen, Sufang Chu, Junnian Zheng, Zhongwei Li, Jin Bai
Format: Article
Language:English
Published: Nature Publishing Group 2024-03-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-01919-2

Internet

https://doi.org/10.1038/s41420-024-01919-2

Similar Items