DdCBE mediates efficient and inheritable modifications in mouse mitochondrial genome

DdCBE mediates efficient and inheritable modifications in mouse mitochondrial genome

Critical mutations of mitochondrial DNA (mtDNA) generally lead to maternally inheritable diseases that affect multiple organs and systems; however, it was difficult to alter mtDNA in mammalian cells to intervene in or cure mitochondrial disorders. Recently, the discovery of DddA-derived cytosine bas...

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Bibliographic Details
Main Authors: Jiayin Guo, Xiaoxu Chen, Zhiwei Liu, Haifeng Sun, Yu Zhou, Yichen Dai, Yu'e Ma, Lei He, Xuezhen Qian, Jianying Wang, Jie Zhang, Yichen Zhu, Jun Zhang, Bin Shen, Fei Zhou
Format: Article
Language:English
Published: Elsevier 2022-03-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
DdCBE
mtDNA
base editing
mouse model
mitochondrial disorder
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121002912

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http://www.sciencedirect.com/science/article/pii/S2162253121002912

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