Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice

Characteristic mutations induced in the small intestine of Msh2-knockout gpt delta mice

Abstract Background Base pair mismatches in genomic DNA can result in mutagenesis, and consequently in tumorigenesis. To investigate how mismatch repair deficiency increases mutagenicity under oxidative stress, we examined the type and frequency of mutations arising in the mucosa of the small intest...

Full description

Bibliographic Details
Main Authors: Yasunobu Aoki, Mizuki Ohno, Michiyo Matsumoto, Michi Matsumoto, Kenichi Masumura, Takehiko Nohmi, Teruhisa Tsuzuki
Format: Article
Language:English
Published: BMC 2021-07-01
Series:Genes and Environment
Subjects:
Mismatch repair
Oxidative stress
Potassium bromate
Single-base deletion
Transgenic rodent assay
Tumorigenesis
Online Access:https://doi.org/10.1186/s41021-021-00196-0

Internet

https://doi.org/10.1186/s41021-021-00196-0

Similar Items