Vascular Immune Evasion of Mesenchymal Glioblastoma Is Mediated by Interaction and Regulation of VE-Cadherin on PD-L1

Vascular Immune Evasion of Mesenchymal Glioblastoma Is Mediated by Interaction and Regulation of VE-Cadherin on PD-L1

The mesenchymal subtype of glioblastoma (mGBM), which is characterized by rigorous vasculature, resists anti-tumor immune therapy. Here, we investigated the mechanistic link between tumor vascularization and the evasion of immune surveillance. Clinical datasets with GBM transcripts showed that the e...

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Bibliographic Details
Main Authors: Jing Luo, Ziyi Wang, Xuemei Zhang, Haihui Yu, Hui Chen, Kun Song, Yang Zhang, Lawrence M. Schwartz, Hongzhuan Chen, Yingbin Liu, Rong Shao
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cancers
Subjects:
YKL-40
VE-cadherin
vascular immune evasion
angiogenesis
PD-L1
glioblastoma (GBM)
Online Access:https://www.mdpi.com/2072-6694/15/17/4257

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https://www.mdpi.com/2072-6694/15/17/4257

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