Pyrancoumarin derivative LP4C targeting of pyrimidine de novo synthesis pathway inhibits MRSA biofilm and virulence

Pyrancoumarin derivative LP4C targeting of pyrimidine de novo synthesis pathway inhibits MRSA biofilm and virulence

Staphylococcus aureus poses a serious public health threat because of its multidrug resistance and biofilm formation ability. Hence, developing novel anti-biofilm agents and finding targets are needed to mitigate the proliferation of drug-resistant pathogens. In our previous study, we showed that th...

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Bibliographic Details
Main Authors: Yongsheng Liu, Shan Su, Moxi Yu, Dongshen Zhai, Yachen Hou, Hui Zhao, Xue Ma, Min Jia, Xiaoyan Xue, Mingkai Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-09-01
Series:Frontiers in Pharmacology
Subjects:
Staphylococcus aureus
biofilm
coumarin
pyrimidine
virulence
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.959736/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.959736/full

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