Anti-Leishmania major activity of Calotropis procera extract by increasing ROS production and upregulating TNF-α, IFN-γ and iNOS mRNA expression under in vitro conditions

Anti-Leishmania major activity of Calotropis procera extract by increasing ROS production and upregulating TNF-α, IFN-γ and iNOS mRNA expression under in vitro conditions

Abstract Background Leishmaniasis, caused by protozoan parasites of the genus Leishmania, is a neglected tropical disease with 700,000 to 1,000,000 global new cases annually. Adverse effects associated with expense, long-term treatment and drug resistance have made conventional therapies unfavorable...

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Bibliographic Details
Main Authors: Shahla Amani, Soheila Alinejad, Negar Asadi, Elham Yousefi, Shahram Khademvatan, Gordon Stanley Howarth
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Tropical Medicine and Health
Subjects:
Amastigote
Calotropis procera
Leishmania major
Promastigote
Gene expression
PBMCs
Online Access:https://doi.org/10.1186/s41182-024-00578-4

Internet

https://doi.org/10.1186/s41182-024-00578-4

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