Crosstalk between G-Quadruplexes and Dnmt3a-Mediated Methylation of the <i>c-MYC</i> Oncogene Promoter

Crosstalk between G-Quadruplexes and Dnmt3a-Mediated Methylation of the <i>c-MYC</i> Oncogene Promoter

The methylation of cytosines at CpG sites in DNA, carried out de novo by DNA methyltransferase Dnmt3a, is a basic epigenetic modification involved in gene regulation and genome stability. Aberrant CpG methylation in gene promoters leads to oncogenesis. In oncogene promoters, CpG sites often colocali...

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Bibliographic Details
Main Authors: Alexander V. Sergeev, Andrei G. Loiko, Adelya I. Genatullina, Alexander S. Petrov, Elena A. Kubareva, Nina G. Dolinnaya, Elizaveta S. Gromova
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:International Journal of Molecular Sciences
Subjects:
G-quadruplexes
<i>c-MYC</i> promoter
DNA methylation
Dnmt3a
DNA–protein interaction
Online Access:https://www.mdpi.com/1422-0067/25/1/45

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https://www.mdpi.com/1422-0067/25/1/45

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