The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines

CaMKv is a pseduokinase of unknown function. Here, the authors identify the protein as a substrate of the protein kinase Cdk5, and show that CaMKv is synthesized in response to neural activity and plays an important role in maintaining dendritic spines, synaptic plasticity, and hippocampal memory vi...

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Bibliographic Details
Main Authors: Zhuoyi Liang, Yi Zhan, Yang Shen, Catherine C. L. Wong, John R. Yates, Florian Plattner, Kwok-On Lai, Nancy Y. Ip
Format: Article
Language:English
Published: Nature Portfolio 2016-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms13282