The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines
CaMKv is a pseduokinase of unknown function. Here, the authors identify the protein as a substrate of the protein kinase Cdk5, and show that CaMKv is synthesized in response to neural activity and plays an important role in maintaining dendritic spines, synaptic plasticity, and hippocampal memory vi...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms13282 |
| _version_ | 1818427142263799808 |
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| author | Zhuoyi Liang Yi Zhan Yang Shen Catherine C. L. Wong John R. Yates Florian Plattner Kwok-On Lai Nancy Y. Ip |
| author_facet | Zhuoyi Liang Yi Zhan Yang Shen Catherine C. L. Wong John R. Yates Florian Plattner Kwok-On Lai Nancy Y. Ip |
| author_sort | Zhuoyi Liang |
| collection | DOAJ |
| description | CaMKv is a pseduokinase of unknown function. Here, the authors identify the protein as a substrate of the protein kinase Cdk5, and show that CaMKv is synthesized in response to neural activity and plays an important role in maintaining dendritic spines, synaptic plasticity, and hippocampal memory via RhoA inhibition. |
| first_indexed | 2024-12-14T14:41:01Z |
| format | Article |
| id | doaj.art-d0ffb0de24424d838846584b6e6c4411 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-14T14:41:01Z |
| publishDate | 2016-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d0ffb0de24424d838846584b6e6c44112022-12-21T22:57:25ZengNature PortfolioNature Communications2041-17232016-10-017111310.1038/ncomms13282The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spinesZhuoyi Liang0Yi Zhan1Yang Shen2Catherine C. L. Wong3John R. Yates4Florian Plattner5Kwok-On Lai6Nancy Y. Ip7Division of Life Science, The Hong Kong University of Science and TechnologyDivision of Life Science, The Hong Kong University of Science and TechnologyDivision of Life Science, The Hong Kong University of Science and TechnologyDepartment of Chemical Physiology, The Scripps Research InstituteState Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and TechnologyDepartment of Psychiatry, University of Texas Southwestern Medical CenterDivision of Life Science, The Hong Kong University of Science and TechnologyDivision of Life Science, The Hong Kong University of Science and TechnologyCaMKv is a pseduokinase of unknown function. Here, the authors identify the protein as a substrate of the protein kinase Cdk5, and show that CaMKv is synthesized in response to neural activity and plays an important role in maintaining dendritic spines, synaptic plasticity, and hippocampal memory via RhoA inhibition.https://doi.org/10.1038/ncomms13282 |
| spellingShingle | Zhuoyi Liang Yi Zhan Yang Shen Catherine C. L. Wong John R. Yates Florian Plattner Kwok-On Lai Nancy Y. Ip The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines Nature Communications |
| title | The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines |
| title_full | The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines |
| title_fullStr | The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines |
| title_full_unstemmed | The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines |
| title_short | The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines |
| title_sort | pseudokinase camkv is required for the activity dependent maintenance of dendritic spines |
| url | https://doi.org/10.1038/ncomms13282 |
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