Glycocalyx components affect platelet function, whole blood coagulation, and fibrinolysis: an in vitro study suggesting a link to trauma-induced coagulopathy

Abstract Background The mechanisms of trauma induced coagulopathy (TIC) are considered multifactorial. Amongst others, however, shedding of the endothelial glycocalyx resulting in increased concentrations of glycocalyx fragments in plasma might also play a role. Thus, we hypothesized that shedded gl...

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Bibliographic Details
Main Authors: Martin W. Britten, Laura Lümers, Kenji Tominaga, Jürgen Peters, Daniel Dirkmann
Format: Article
Language:English
Published: BMC 2021-03-01
Series:BMC Anesthesiology
Subjects:
Online Access:https://doi.org/10.1186/s12871-021-01300-1