Bioequivalence of Oral Drug Products in the Healthy and Special Populations: Assessment and Prediction Using a Newly Developed In Vitro System “BE Checker”

Bioequivalence of Oral Drug Products in the Healthy and Special Populations: Assessment and Prediction Using a Newly Developed In Vitro System “BE Checker”

In order to assess and predict the bioequivalence (BE) of oral drug products, a new in vitro system “BE checker” was developed, which reproduced the environmental changes in the gastrointestinal (GI) tract by changing the pH, composition, and volume of the medium in a single chamber. The dissolution...

Full description

Bibliographic Details
Main Authors: Takato Masada, Toshihide Takagi, Keiko Minami, Makoto Kataoka, Ken-ichi Izutsu, Kazuki Matsui, Shinji Yamashita
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
oral drug product
bioequivalence
special population
gastrointestinal physiology
dissolution
permeation
Online Access:https://www.mdpi.com/1999-4923/13/8/1136

Internet

https://www.mdpi.com/1999-4923/13/8/1136

Similar Items