Structure‐Activity Relationship of NF023 Derivatives Binding to XIAP‐BIR1

Structure‐Activity Relationship of NF023 Derivatives Binding to XIAP‐BIR1

Abstract Inhibitors of Apoptosis Proteins (IAPs) are conserved E3‐ligases that ubiquitylate substrates to prevent apoptosis and activate the NF‐kB survival pathway, often deregulated in cancer. IAPs‐mediated regulation of NF‐kB signaling is based on the formation of protein complexes by their type‐I...

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Bibliographic Details
Main Authors: Dr. Luca Sorrentino, Dr. Federica Cossu, Dr. Mario Milani, Bilge Malkoc, Dr. Wen‐Chieh Huang, Dr. Shwu‐Chen Tsay, Prof. Jih Ru Hwu, Dr. Eloise Mastrangelo
Format: Article
Language:English
Published: Wiley-VCH 2019-04-01
Series:ChemistryOpen
Subjects:
apoptosis
drug discovery
structure-activity relationship
in silico docking
protein structures
Online Access:https://doi.org/10.1002/open.201900059

Internet

https://doi.org/10.1002/open.201900059

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