Multiple renal cyst development but not situs abnormalities in transgenic RNAi mice against Inv::GFP rescue gene.

Multiple renal cyst development but not situs abnormalities in transgenic RNAi mice against Inv::GFP rescue gene.

In this study we generated RNA interference (RNAi)-mediated gene knockdown transgenic mice (transgenic RNAi mice) against the functional Inv gene. Inv mutant mice show consistently reversed internal organs (situs inversus), multiple renal cysts and neonatal lethality. The Inv::GFP-rescue mice, which...

Full description

Bibliographic Details
Main Authors: Yuki Kamijho, Yayoi Shiozaki, Eiki Sakurai, Kazunori Hanaoka, Daisuke Watanabe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3933642?pdf=render

Internet

http://europepmc.org/articles/PMC3933642?pdf=render

Similar Items