Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study.

Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study.

<h4>Background</h4>Osteoporosis and fracture risk are considered to be under genetic control. Extensive work is being performed to identify the exact genetic variants that determine this risk. Previous work has suggested that a G/T polymorphism affecting an Sp1 binding site in the COLIA1...

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Detalhes bibliográficos
Main Authors: Stuart H Ralston, André G Uitterlinden, Maria Luisa Brandi, Susana Balcells, Bente L Langdahl, Paul Lips, Roman Lorenc, Barbara Obermayer-Pietsch, Serena Scollen, Mariona Bustamante, Lise Bjerre Husted, Alisoun H Carey, Adolfo Diez-Perez, Alison M Dunning, Alberto Falchetti, Elzbieta Karczmarewicz, Marcin Kruk, Johannes P T M van Leeuwen, Joyce B J van Meurs, Jon Mangion, Fiona E A McGuigan, Leonardo Mellibovsky, Francesca del Monte, Huibert A P Pols, Jonathan Reeve, David M Reid, Wilfried Renner, Fernando Rivadeneira, Natasja M van Schoor, Rachael E Sherlock, John P A Ioannidis, GENOMOS Investigators
Formato: Artigo
Idioma:English
Publicado em: Public Library of Science (PLoS) 2006-04-01
Colecção:PLoS Medicine
Acesso em linha:https://doi.org/10.1371/journal.pmed.0030090

Internet

https://doi.org/10.1371/journal.pmed.0030090

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