High-Resolution Structure Analysis of Antibody V5 and U4 Conformational Epitopes on Human Papillomavirus 16

High-Resolution Structure Analysis of Antibody V5 and U4 Conformational Epitopes on Human Papillomavirus 16

Cancers attributable to human papillomavirus (HPV) place a huge burden on the health of both men and women. The current commercial vaccines are genotype specific and provide little therapeutic benefit to patients with existing HPV infections. Identifying the conformational epitopes on the virus caps...

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Bibliographic Details
Main Authors: Jian Guan, Stephanie M. Bywaters, Sarah A. Brendle, Robert E. Ashley, Alexander M. Makhov, James F. Conway, Neil D. Christensen, Susan Hafenstein
Format: Article
Language:English
Published: MDPI AG 2017-12-01
Series:Viruses
Subjects:
human papillomavirus
cryo-electron Microscopy (cryo-EM)
conformational epitope
antibody neutralization
U4 and V5
competition
steric clash
complex
virus
fab
Online Access:https://www.mdpi.com/1999-4915/9/12/374

Internet

https://www.mdpi.com/1999-4915/9/12/374

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