New insights into epigenetic regulation of resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms and therapeutic opportunities

New insights into epigenetic regulation of resistance to PD-1/PD-L1 blockade cancer immunotherapy: mechanisms and therapeutic opportunities

Abstract Programmed cell death protein 1(PD-1) is a type of immune-inhibitory checkpoint protein, which delivers inhibitory signals to cytotoxic T cells by binding to the programmed death ligand-1 (PD-L1) displayed on the surface of cancer cells. Antibodies blocking PD-1/PD-L1 interaction have been...

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Bibliographic Details
Main Authors: Mengyuan Dai, Miao Liu, Hua Yang, Can Küçük, Hua You
Format: Article
Language:English
Published: BMC 2022-11-01
Series:Experimental Hematology & Oncology
Subjects:
PD-1/PD-L1
Immune checkpoints
Therapy resistance
Epigenetic regulation
DNA methyltransferase
Histone deacetylase
Online Access:https://doi.org/10.1186/s40164-022-00356-0

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https://doi.org/10.1186/s40164-022-00356-0

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