Gelsolin Contributes to the Motility of A375 Melanoma Cells and This Activity Is Mediated by the Fibrous Extracellular Matrix Protein Profile

Gelsolin Contributes to the Motility of A375 Melanoma Cells and This Activity Is Mediated by the Fibrous Extracellular Matrix Protein Profile

Skin melanocytes reside on the basement membrane (BM), which is mainly composed of laminin, collagen type IV, and proteoglycans. For melanoma cells, in order to invade into the skin, melanocytes must cross the BM. It has been reported that changes in the composition of the BM accompany melanocytes t...

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Detalles Bibliográficos
Autores principales: Ewa Mazurkiewicz, Aleksandra Makowiecka, Ewa Mrówczyńska, Iryna Kopernyk, Dorota Nowak, Antonina Joanna Mazur
Formato: Artículo
Lenguaje:English
Publicado: MDPI AG 2021-07-01
Colección:Cells
Materias:
gelsolin (GSN)
CRISPR/Cas9(D10A) technique
melanoma
motility
invasion
extracellular matrix (ECM)
Acceso en línea:https://www.mdpi.com/2073-4409/10/8/1848

Internet

https://www.mdpi.com/2073-4409/10/8/1848

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