Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities
A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good inhibitory effect against the adhesion and migrat...
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| Format: | Article |
| Language: | English |
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MDPI AG
2014-06-01
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| Series: | Molecules |
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| Online Access: | http://www.mdpi.com/1420-3049/19/7/8916 |
| _version_ | 1828403801988530176 |
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| author | Guangjin Yu Zeng Li Liang Tang Qiru Xiong |
| author_facet | Guangjin Yu Zeng Li Liang Tang Qiru Xiong |
| author_sort | Guangjin Yu |
| collection | DOAJ |
| description | A series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good inhibitory effect against the adhesion and migration of human umbilical vein endothelial cells (HUVECs). Among these compounds, 11d was the most potent agent, that also exhibited the highest anti-angiogenesis activities in the chick embryo chorioallantoic membrane (CAM) assay. |
| first_indexed | 2024-12-10T10:24:54Z |
| format | Article |
| id | doaj.art-d10da2893b314522a934bd4b889db7c9 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-12-10T10:24:54Z |
| publishDate | 2014-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d10da2893b314522a934bd4b889db7c92022-12-22T01:52:46ZengMDPI AGMolecules1420-30492014-06-011978916893210.3390/molecules19078916molecules19078916Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis ActivitiesGuangjin Yu0Zeng Li1Liang Tang2Qiru Xiong3Department of Chirurgery, First Affiliated Hospital of Anhui Medical University, Hefei 230032, ChinaDepartment of Chemistry, Anhui Medical University, Hefei 230032, ChinaDepartment of Chirurgery, First Affiliated Hospital of Anhui Medical University, Hefei 230032, ChinaDepartment of Chirurgery, First Affiliated Hospital of Anhui Medical University, Hefei 230032, ChinaA series of 2,4-disubstituted quinazoline derivatives were designed and synthesized. The biological results showed that most of quinazoline derivatives exhibited potent antiproliferative activities against a panel of three tumor cell lines and a good inhibitory effect against the adhesion and migration of human umbilical vein endothelial cells (HUVECs). Among these compounds, 11d was the most potent agent, that also exhibited the highest anti-angiogenesis activities in the chick embryo chorioallantoic membrane (CAM) assay.http://www.mdpi.com/1420-3049/19/7/89162,4-disubstituted quinazoline derivativessynthesisanti-angiogenesis |
| spellingShingle | Guangjin Yu Zeng Li Liang Tang Qiru Xiong Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities Molecules 2,4-disubstituted quinazoline derivatives synthesis anti-angiogenesis |
| title | Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities |
| title_full | Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities |
| title_fullStr | Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities |
| title_full_unstemmed | Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities |
| title_short | Synthesis and Evaluation of 2,4-Disubstituted Quinazoline Derivatives with Potent Anti-Angiogenesis Activities |
| title_sort | synthesis and evaluation of 2 4 disubstituted quinazoline derivatives with potent anti angiogenesis activities |
| topic | 2,4-disubstituted quinazoline derivatives synthesis anti-angiogenesis |
| url | http://www.mdpi.com/1420-3049/19/7/8916 |
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