Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.

Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.

Impaired lung function in early life is associated with the subsequent development of chronic respiratory disease. Most genetic associations with lung function have been identified in adults of European descent and therefore may not represent those most relevant to pediatric populations and populati...

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Bibliographic Details
Main Authors: Matthew Dapas, Emma E Thompson, William Wentworth-Sheilds, Selene Clay, Cynthia M Visness, Agustin Calatroni, Joanne E Sordillo, Diane R Gold, Robert A Wood, Melanie Makhija, Gurjit K Khurana Hershey, Michael G Sherenian, Rebecca S Gruchalla, Michelle A Gill, Andrew H Liu, Haejin Kim, Meyer Kattan, Leonard B Bacharier, Deepa Rastogi, Matthew C Altman, William W Busse, Patrice M Becker, Dan Nicolae, George T O'Connor, James E Gern, Daniel J Jackson, Carole Ober
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS Genetics
Online Access:https://doi.org/10.1371/journal.pgen.1010594

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https://doi.org/10.1371/journal.pgen.1010594

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