Screening and Identification of the First Non-CRISPR/Cas9-Treated Chinese Miniature Pig With Defective Porcine Endogenous Retrovirus pol Genes

Screening and Identification of the First Non-CRISPR/Cas9-Treated Chinese Miniature Pig With Defective Porcine Endogenous Retrovirus pol Genes

Pig to human xenotransplantation is considered to be a possible approach to alleviate the shortage of human allografts. Porcine endogenous retrovirus (PERV) is the most significant pathogen in xenotransplantation. We screened for pigs that consistently did not transmit human-tropic replication compe...

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Bibliographic Details
Main Authors: Yuyuan Ma, Junting Jia, Rui Fan, Ying Lu, Xiong Zhao, Yadi Zhong, Jierong Yang, Limin Ma, Yanlin Wang, Maomin Lv, Haiyuan Yang, Lisha Mou, Yifan Dai, Shutang Feng, Jingang Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
porcine endogenous retrovirus
Chinese miniature pig
defective gene
inbreeding
whole-genome resequencing
full-length transcriptome sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.797608/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.797608/full

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