RU.521 mitigates subarachnoid hemorrhage-induced brain injury via regulating microglial polarization and neuroinflammation mediated by the cGAS/STING/NF-κB pathway

RU.521 mitigates subarachnoid hemorrhage-induced brain injury via regulating microglial polarization and neuroinflammation mediated by the cGAS/STING/NF-κB pathway

Abstract Background The poor prognosis of subarachnoid hemorrhage (SAH) is often attributed to neuroinflammation. The cGAS-STING axis, a cytoplasmic pathway responsible for detecting dsDNA, plays a significant role in mediating neuroinflammation in neurological diseases. However, the effects of inhi...

Full description

Bibliographic Details
Main Authors: Jiang Shao, Yuxiao Meng, Kaikun Yuan, Qiaowei Wu, Shiyi Zhu, Yuchen Li, Pei Wu, Jiaolin Zheng, Huaizhang Shi
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Cell Communication and Signaling
Subjects:
Subarachnoid hemorrhage
Early brain injury
cGAS
STING
NF-κB
Microglia
Online Access:https://doi.org/10.1186/s12964-023-01274-2

Internet

https://doi.org/10.1186/s12964-023-01274-2

Similar Items