Host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons

Host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons

Introduction: Cell therapeutic clinical trials using fetal mesencephalic tissue provided a proof-of-concept for regenerative therapy in patients with Parkinson's disease. Postmortem studies of patients with fetal grafts revealed that α-synuclein+ Lewy body (LB)-like inclusions emerged in long-t...

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Bibliographic Details
Main Authors: Serina Gima, Kazuya Oe, Kaneyasu Nishimura, Takashi Ohgita, Haruka Ito, Hiroyuki Kimura, Hiroyuki Saito, Kazuyuki Takata
Format: Article
Language:English
Published: Elsevier 2024-03-01
Series:Regenerative Therapy
Subjects:
Human induced pluripotent stem cells
Dopaminergic neurons
Cell transplantation
α-synuclein
Online Access:http://www.sciencedirect.com/science/article/pii/S2352320423001529

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http://www.sciencedirect.com/science/article/pii/S2352320423001529

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