Structuring detergents for extracting and stabilizing functional membrane proteins.

Structuring detergents for extracting and stabilizing functional membrane proteins.

BACKGROUND: Membrane proteins are privileged pharmaceutical targets for which the development of structure-based drug design is challenging. One underlying reason is the fact that detergents do not stabilize membrane domains as efficiently as natural lipids in membranes, often leading to a partial t...

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Bibliographic Details
Main Authors: Rima Matar-Merheb, Moez Rhimi, Antoine Leydier, Frédéric Huché, Carmen Galián, Elodie Desuzinges-Mandon, Damien Ficheux, David Flot, Nushin Aghajari, Richard Kahn, Attilio Di Pietro, Jean-Michel Jault, Anthony W Coleman, Pierre Falson
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3069034?pdf=render

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http://europepmc.org/articles/PMC3069034?pdf=render

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