Matrix metallopeptidase 9 contributes to the beginning of plaque and is a potential biomarker for the early identification of atherosclerosis in asymptomatic patients with diabetes

Matrix metallopeptidase 9 contributes to the beginning of plaque and is a potential biomarker for the early identification of atherosclerosis in asymptomatic patients with diabetes

AimsTo determine the roles of matrix metallopeptidase-9 (MMP9) on human coronary artery smooth muscle cells (HCASMCs) in vitro, early beginning of atherosclerosis in vivo in diabetic mice, and drug naïve patients with diabetes.MethodsActive human MMP9 (act-hMMP9) was added to HCASMCs and the express...

Full description

Bibliographic Details
Main Authors: Bingli Liu, Liping Su, Sze Jie Loo, Yu Gao, Ester Khin, Xiaocen Kong, Rinkoo Dalan, Xiaofei Su, Kok-Onn Lee, Jianhua Ma, Lei Ye
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-04-01
Series:Frontiers in Endocrinology
Subjects:
atherosclerosis
type 2 diabetes
matrix metallopeptidase 9
inflammation
ischemic heart disease
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1369369/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2024.1369369/full

Similar Items