Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI.

Successful targeting and disruption of an integrated reporter lentivirus using the engineered homing endonuclease Y2 I-AniI.

Current antiviral therapy does not cure HIV-infected individuals because the virus establishes lifelong latent infection within long-lived memory T cells as integrated HIV proviral DNA. Here, we report a new therapeutic approach that aims to cure cells of latent HIV infection by rendering latent vir...

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Bibliographic Details
Main Authors: Martine Aubert, Byoung Y Ryu, Lindsey Banks, David J Rawlings, Andrew M Scharenberg, Keith R Jerome
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-02-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3036713?pdf=render

Internet

http://europepmc.org/articles/PMC3036713?pdf=render

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