Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling

Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling

Abstract Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine therapies. ESR1 mutations have been implicated in therapy resistance in metastatic breast cancer, in particular to aromatase inhibito...

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Bibliographic Details
Main Authors: Tommaso De Marchi, Chun-Fui Lai, Georgia M. Simmons, Isabella Goldsbrough, Alison Harrod, Thai Lam, Lakjaya Buluwela, Sven Kjellström, Christian Brueffer, Lao H. Saal, Johan Malmström, Simak Ali, Emma Niméus
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-024-56412-8

Internet

https://doi.org/10.1038/s41598-024-56412-8

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