Altered Transcription Factor Binding and Gene Bivalency in Islets of Intrauterine Growth Retarded Rats

Altered Transcription Factor Binding and Gene Bivalency in Islets of Intrauterine Growth Retarded Rats

Intrauterine growth retardation (IUGR), which induces epigenetic modifications and permanent changes in gene expression, has been associated with the development of type 2 diabetes. Using a rat model of IUGR, we performed ChIP-Seq to identify and map genome-wide histone modifications and gene dysreg...

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Bibliographic Details
Main Authors: Yu-Chin Lien, Paul Zhiping Wang, Xueqing Maggie Lu, Rebecca A. Simmons
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cells
Subjects:
islets
histone modifications
ChIP-Seq
intrauterine growth restriction
epigenetics
transcription factor binding motif
Online Access:https://www.mdpi.com/2073-4409/9/6/1435

Internet

https://www.mdpi.com/2073-4409/9/6/1435

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