Purinergic receptors are a key bottleneck in tumor metabolic reprogramming: The prime suspect in cancer therapeutic resistance

Purinergic receptors are a key bottleneck in tumor metabolic reprogramming: The prime suspect in cancer therapeutic resistance

ATP and other nucleoside phosphates have specific receptors named purinergic receptors. Purinergic receptors and ectonucleotidases regulate various signaling pathways that play a role in physiological and pathological processes. Extracellular ATP in the tumor microenvironment (TME) has a higher leve...

Full description

Bibliographic Details
Main Authors: Hamid Aria, Marzieh Rezaei, Shima Nazem, Abdolreza Daraei, Ghasem Nikfar, Behnam Mansoori, Maryam Bahmanyar, Alireza Tavassoli, Mohammad Kazem Vakil, Yaser Mansoori
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-08-01
Series:Frontiers in Immunology
Subjects:
therapy resistance
tumor microenvironment
metabolic reprogramming
purinergic receptor
cancer metabolism
immunometabolism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.947885/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.947885/full

Similar Items