The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning

The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning

Neuronal ApoE receptors are linked to learning and memory, but the pathways governing their abundance, and the mechanisms by which they affect the function of neural circuits are incompletely understood. Here we demonstrate that the E3 ubiquitin ligase IDOL determines synaptic ApoER2 protein levels...

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Bibliographic Details
Main Authors: Jie Gao, Mate Marosi, Jinkuk Choi, Jennifer M Achiro, Sangmok Kim, Sandy Li, Klara Otis, Kelsey C Martin, Carlos Portera-Cailliau, Peter Tontonoz
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-09-01
Series:eLife
Subjects:
lipoprotein receptor
ApoE
dendritic spines
ubiquitin ligase
Online Access:https://elifesciences.org/articles/29178

Internet

https://elifesciences.org/articles/29178

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