Proximal Tubular <i>Lats2</i> Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53

Proximal Tubular <i>Lats2</i> Ablation Exacerbates Ischemia/Reperfusion Injury (IRI)-Induced Renal Maladaptive Repair through the Upregulation of P53

The Hippo pathway mediates renal maladaptive repair after acute kidney injury (AKI), which has been considered a driving force in the progression to chronic kidney disease (CKD). LATS2, a core kinase of the Hippo pathway, exerts non-Hippo-dependent functions in the regulation of the cell cycle and c...

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Bibliographic Details
Main Authors: Chi Zhang, Zhihuang Zheng, Kexin Xu, Guozhe Cheng, Huijuan Wu, Jun Liu
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
LATS2
p53
acute kidney injury
maladaptive repair
apoptosis
Online Access:https://www.mdpi.com/1422-0067/24/20/15258

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https://www.mdpi.com/1422-0067/24/20/15258

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