Protein and functional isoform levels and genetic variants of the BAFF and APRIL pathway components in systemic lupus erythematosus

Protein and functional isoform levels and genetic variants of the BAFF and APRIL pathway components in systemic lupus erythematosus

Abstract Systemic lupus erythematosus (SLE) is the prototype of an autoimmune disease. Belimumab, a monoclonal antibody targets BAFF, is the only biologic approved for SLE and active lupus nephritis. BAFF is a cytokine with a key-regulatory role in the B cell homeostasis, which acts by binding to th...

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Bibliographic Details
Main Authors: Pilar Ortiz-Aljaro, Marco Antonio Montes-Cano, José-Raúl García-Lozano, Virginia Aquino, Rosario Carmona, Javier Perez-Florido, Francisco José García-Hernández, Joaquín Dopazo, María Francisca González-Escribano
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-15549-0

Internet

https://doi.org/10.1038/s41598-022-15549-0

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