Novel Pharmaceutical Strategy for Selective Abrogation of TSP1-Induced Vascular Dysfunction by Decoy Recombinant CD47 Soluble Receptor in Prophylaxis and Treatment Models

Novel Pharmaceutical Strategy for Selective Abrogation of TSP1-Induced Vascular Dysfunction by Decoy Recombinant CD47 Soluble Receptor in Prophylaxis and Treatment Models

Elevated thrombospondin 1 (TSP1) is a prevalent factor, via cognate receptor CD47, in the pathogenesis of cardiovascular conditions, including ischemia-reperfusion injury (IRI) and pulmonary arterial hypertension (PAH). Moreover, TSP1/CD47 interaction has been found to be associated with platelet hy...

Full description

Bibliographic Details
Main Authors: Molly Yao, Jalicia Sturdivant, Aren Ebrahimi, Samayita Ganguly, Tamer Elbayoumi
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:Biomedicines
Subjects:
thrombospondin 1
CD47
decoy receptor protein
vasorelaxation
endothelium
pulmonary arterial hypertension
Online Access:https://www.mdpi.com/2227-9059/9/6/642

Internet

https://www.mdpi.com/2227-9059/9/6/642

Similar Items