Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts

Parental genomes segregate into distinct blastomeres during multipolar zygotic divisions leading to mixoploid and chimeric blastocysts

Abstract Background During normal zygotic division, two haploid parental genomes replicate, unite and segregate into two biparental diploid blastomeres. Results Contrary to this fundamental biological tenet, we demonstrate here that parental genomes can segregate to distinct blastomeres during the z...

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Bibliographic Details
Main Authors: Tine De Coster, Heleen Masset, Olga Tšuiko, Maaike Catteeuw, Yan Zhao, Nicolas Dierckxsens, Ainhoa Larreategui Aparicio, Eftychia Dimitriadou, Sophie Debrock, Karen Peeraer, Marta de Ruijter-Villani, Katrien Smits, Ann Van Soom, Joris Robert Vermeesch
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Genome Biology
Subjects:
Zygote
Mitosis
Whole-genome segregation errors
Chromosomal instability
Triploidy
Chimerism
Online Access:https://doi.org/10.1186/s13059-022-02763-2

Internet

https://doi.org/10.1186/s13059-022-02763-2

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