Psoralen synergizes with exosome-loaded SPC25 to alleviate senescence of nucleus pulposus cells in intervertebral disc degeneration

Psoralen synergizes with exosome-loaded SPC25 to alleviate senescence of nucleus pulposus cells in intervertebral disc degeneration

Abstract Objective To explore the mechanism of psoralen synergized with exosomes (exos)-loaded SPC25 on nucleus pulposus (NP) cell senescence in intervertebral disc degeneration (IVDD). Methods IVDD cellular models were established on NP cells by tert-butyl hydroperoxide (TBHP) induction, followed b...

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Bibliographic Details
Main Authors: Lei Yang, Zhaoyong Li, Chao Zhang, Shuofu Li, Long Chen, Shaofeng Yang, Yantao Guo
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Journal of Orthopaedic Surgery and Research
Subjects:
Psoralen
Exosomes
SPC25
Nucleus pulposus
Senescence
Intervertebral disc degeneration
Online Access:https://doi.org/10.1186/s13018-023-04085-w

Internet

https://doi.org/10.1186/s13018-023-04085-w

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