Overexpression of Wild Type But Not an FAD Mutant Presenilin-1 Promotes Neurogenesis in the Hippocampus of Adult Mice

Overexpression of Wild Type But Not an FAD Mutant Presenilin-1 Promotes Neurogenesis in the Hippocampus of Adult Mice

Mutations in the presenilin-1 (PS-1) gene are one cause of familial Alzheimer's disease (FAD). However, the functions of the PS-1 protein as well as how PS-1 mutations cause FAD are incompletely understood. Here we investigated if neuronal overexpression of wild-type or FAD mutant PS-1 in trans...

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Main Authors: Paul H. Wen, Xiang Shao, Zhiping Shao, Patrick R. Hof, Thomas Wisniewski, Kevin Kelley, Victor L. Friedrich, Jr., Lap Ho, Giulio M. Pasinetti, Junichi Shioi, Nikolaos K. Robakis, Gregory A. Elder
Format: Article
Language:English
Published: Elsevier 2002-06-01
Series:Neurobiology of Disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996102904900

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http://www.sciencedirect.com/science/article/pii/S0969996102904900

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